The recent technology has brought in non invasive treatment modalities, which is considered to be a progress in the lithotripsy techniques. Also there has been considerable development in the endoscopes along with making use of energy resources of the likes of electro-hydraulic, ultrasonic and laser etc.

However, these remedies have brought in a few problems as well. There are very high chances of residual fragments that give rise to new stone formation. In addition to this, the main problem is that the current practices do not address the problem of primary metabolic disorder. Also, there is a possibility that the medicines today might have some or the other side effects. Ayurveda also has mentioned numerous herbal remedies, which are supposed to have anti-urolithiasis and or diuretic activity. However, there has been hardly any scientific trial data which can confirm the validity of herbal medicines for the treatment of urinary calculi.

Currently a detailed research on the formulation that helps the expulsion of small stone or also some research on preventing the occurrence of stone is required. However there is hardly any evidence based literature which can be helpful to dissolve or reduce the size of the stone.

In order to have a scientific study of herbal medicine as per the protocols of modern science that are applied to the New Chemical Entity along with the necessary modifications, we have come up with a new technique of Reverse Pharmacology. Reverse pharmacology is the science of integrating documented clinical or experiential hits into leads, making the use of transdisciplinary exploratory studies and further developing these into drug candidates by experimental and clinical research.